Dr. Len Leshin, who maintains the website www.ds-health.com and is father to a son with DS, has this to say about the Standford research on PTZ:
“I did see this. This goes along with an earlier study by Dr. Mobley at Stanford Univ. back in 2004 regarding GABA antagonists in a mouse model of DS.
There are two concerns here. First, the use of pentylenetetrazole, which is used currently only to produce seizures in mice. It has been unavailable for human use in the US for about 20 years due to the side effect of increased seizures in humans, and people with DS are more likely to suffer seizures than the general population. Hopefully a different GABA antagonist can be found. Second, past experience has shown that drugs that potentiate learning in mice don’t translate well to humans. It will take, unfortunately, another 10 to 15 years before this research can be useful to people with DS.”
Thanks to moderator Emdad at Downsyn.com for posting Dr. Leshin’s reply.